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PhiKan 083
CAS No. 880813-36-5
PhiKan 083( —— )
Catalog No. M22064 CAS No. 880813-36-5
PhiKan 083 is a carbazole derivative PhiKan 083 reduces the cell viability of engineered variants of Ln229 cells, in conbination with NSC 123127 (1 μM) enhances the pro-apoptotic activity in all variants of Ln229 cells.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 58 | In Stock |
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| 10MG | 102 | In Stock |
|
| 25MG | 222 | In Stock |
|
| 50MG | 331 | In Stock |
|
| 100MG | 489 | In Stock |
|
| 500MG | 1044 | In Stock |
|
| 1G | Get Quote | In Stock |
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Biological Information
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Product NamePhiKan 083
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NoteResearch use only, not for human use.
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Brief DescriptionPhiKan 083 is a carbazole derivative PhiKan 083 reduces the cell viability of engineered variants of Ln229 cells, in conbination with NSC 123127 (1 μM) enhances the pro-apoptotic activity in all variants of Ln229 cells.
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DescriptionPhiKan 083 is a carbazole derivative PhiKan 083 reduces the cell viability of engineered variants of Ln229 cells, in conbination with NSC 123127 (1 μM) enhances the pro-apoptotic activity in all variants of Ln229 cells (p53wt, p53Y220C, p53G245S, p53R282W).
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In VitroPhiKan 083 is a carbazole derivative, which binds to the surface cavity and stabilizes Y220C (a p53 mutant), with a Kd of 167 μM, shows a relative binding affinity (Kd) of 150 μM for p53Y220C in Ln229 cells.PhiKan 083 slows down its thermal denaturation rate.PhiKan 083 (125 μM, 48 hours) reduces the cell viability of engineered variants of Ln229 cells. PhiKan 083 (100 μM) in conbination with NSC 123127 (1 μM) enhances the pro-apoptotic activity in all variants of Ln229 cells (p53wt, p53Y220C, p53G245S, p53R282W). Cell Viability Assay Cell Line:Ln229, Ln229-p53-wt, Ln229-p53-Y220C, Ln229-p53-G245S, Ln229-p53-R282W cells Concentration:125 μMIncubation Time:48 hours Result:Caused ～70 ± 5% reduction in cell viability of variants of Ln229 cells.
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In Vivo——
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Synonyms——
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PathwayApoptosis
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TargetMDM2-p53
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Recptorp53/MDM2
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Research Area——
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Indication——
Chemical Information
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CAS Number880813-36-5
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Formula Weight238.33
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Molecular FormulaC16H18N2
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Purity>98% (HPLC)
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SolubilityDMSO:115 mg/mL (482.52 mM; Need ultrasonic); Ethanol:100 mg/mL (419.59 mM; Need ultrasonic)
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SMILESCCN1C2=CC=CC=C2C2=C1C=CC(CNC)=C2
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Paulmurugan R, et al. A protein folding molecular imaging biosensor monitors the effects of drugs that restore mutant p53 structure and its downstream function in glioblastoma cells. Oncotarget. 2018 Apr 20;9(30):21495-21511.2. Boeckler FM, et al. Targeted rescue of a destabilized mutant of p53 by an in silico screened drug. Proc Natl Acad Sci U S A. 2008 Jul 29;105(30):10360-5.3. Rauf SM, et al. Effect of Y220C mutation on p53 and its rescue mechanism: a computer chemistry approach. Protein J. 2013 Jan;32(1):68-74.
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