PhiKan 083

Research use only, not for human use.

PhiKan 083 is a carbazole derivative PhiKan 083 reduces the cell viability of engineered variants of Ln229 cells, in conbination with NSC 123127 (1 μM) enhances the pro-apoptotic activity in all variants of Ln229 cells.

PhiKan 083 is a carbazole derivative PhiKan 083 reduces the cell viability of engineered variants of Ln229 cells, in conbination with NSC 123127 (1 μM) enhances the pro-apoptotic activity in all variants of Ln229 cells (p53wt, p53Y220C, p53G245S, p53R282W).

PhiKan 083 is a carbazole derivative, which binds to the surface cavity and stabilizes Y220C (a p53 mutant), with a Kd of 167 μM, shows a relative binding affinity (Kd) of 150 μM for p53Y220C in Ln229 cells.PhiKan 083 slows down its thermal denaturation rate.PhiKan 083 (125 μM, 48 hours) reduces the cell viability of engineered variants of Ln229 cells. PhiKan 083 (100 μM) in conbination with NSC 123127 (1 μM) enhances the pro-apoptotic activity in all variants of Ln229 cells (p53wt, p53Y220C, p53G245S, p53R282W). Cell Viability Assay Cell Line:Ln229, Ln229-p53-wt, Ln229-p53-Y220C, Ln229-p53-G245S, Ln229-p53-R282W cells Concentration:125 μMIncubation Time:48 hours Result:Caused ～70 ± 5% reduction in cell viability of variants of Ln229 cells.

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Apoptosis

MDM2-p53

p53/MDM2

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880813-36-5

238.33

C16H18N2

>98% (HPLC)

DMSO:115 mg/mL (482.52 mM; Need ultrasonic); Ethanol:100 mg/mL (419.59 mM; Need ultrasonic)

CCN1C2=CC=CC=C2C2=C1C=CC(CNC)=C2

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(-20℃)

With Ice Pack

≥ 2 years